Pain is a big problem. At least 75% client coming to medical practice or emergency room related to this complain.1 Medication and non-medication therapy usually use to treat that but for sure not one hundred percent can helping all cases. Especially for arthritis who had complex issue for that treatment.
In recent years, science has witnessed a revolutionary breakthrough regenerative medicine. , primarily through the advancement and application of stem cell therapy. This therapy make new hope for holistic treatment on that problem.
What Are Stem Cells?
Stem cells are precursor cells who have ability to self-renew, high plasticity, can stay in an undifferentiated state, have a long life span and can transdifferentiate.2 This unique feature of stem cells, known as potency, highlights their central role in regenerative therapy on arthritis cases especially for osteoarthritis.
There are two types of stem cells: Embryonic stem cell and Adult stem cells. Embryonic stem cell are 3-5 days old derived from blastocyst who have ability to either divide into more stem cells or become any type of cell in the body. It is mean can play critical role in regenerating or repairing damaged tissues and organs.
Adult stem cells have ability to transform into various cell of the body limited and found in small numbers across most adult tissues.
How Benefit of Stem Cell Therapy?
Stem cell therapy is one of regenerative treatment method who had potentially to be delaying osteoarthritis progression and tissue repair. Mesenchymal stem cells (MSC) have advantage to differentiate into chondrocytes and their potential to prevent apoptosis and degeneration.2 Its mean that stem cell can helping by natural healing, decrease pain and increase functionality. Study from Sommya et al (2019) at Canada for 12 patients with moderate to advanced knee osteoarthritis show safely reduced pain and stiffness one year after injection. In Indonesia dose of stem cell therapy for osteoarthritis can be give 3 times with interval 1 week. Grade 3-4 of that can be following by treatment of Platelet Rich Plasma (PRP), Platelet Rich Fibrin (PRF) or scaffold natural/sintetis.4
Indication for osteoarthritis with stem cell therapy are:
- Osteoarthritis who had chronic cartilage damage
- Osteoarthritis that failure with pharmacologic or non-pharmacologic treatment
- Adjuvant therapy for osteoarthritis grade 3-4 who not agree with surgery treatment
Stem cell not just for osteoarthritis but also for injury of muscle, ligament, increase healing of bone fracture, regenerative cell, etc. In Indonesia there are regulation about stem cells include Peraturan Menteri Kesehatan Republik Indonesia Nomor 32 Tahun 2018 Tentang Penyelenggaraan Pelayanan Sel Punca Dan/Atau Sel And Keputusan Menteri Kesehatan Republik Indonesia Nomor Hk.01.07/Menkes/1359/2024 Tentang Pedoman Penyelenggaraan Pelayanan Terapi Sel Punca di Bidang Orthopaedi dan Traumatologi
Amazed by the benefits of stem cell therapy? Contact us at Kertha Usada Hospital
- Downey LV, Zun LS. Pain management in the emergency department and its relationship to patient satisfaction. J Emerg Trauma Shock. 2010 Oct;3(4):326-30.
- Thoene M, Bejer-Olenska E, Wojtkiewicz J. The Current State of Osteoarthritis Treatment Options Using Stem Cells for Regenerative Therapy: A Review. Int J Mol Sci. 2023 May 18;24(10):8925
- Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, Chisholm J, Weston A, Chiovitti J, Keating A, Kapoor M, Ogilvie-Harris DJ, Syed KA, Gandhi R, Mahomed NN, Marshall KW, Sussman MS, Naraghi AM, Viswanathan S. Bone marrow mesenchymal stromal cells in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation. Stem Cells Transl Med. 2019;8(8):746-757.
- Keputusan Menteri Kesehatan Republik Indonesia Nomor Hk.01.07/Menkes/1359/2024 Tentang Pedoman Penyelenggaraan Pelayanan Terapi Sel Punca di Bidang Orthopaedi dan Traumatologi
Oleh :
- Putu Kermawan, Sp.OT, M.Biomed(IKD),AIFO-K, FICS
- dr Putu Sukedana, S.Ked AIFO-K